Turmeric, pt. 3, Will it help Parkinson’s?

http://www.ncbi.nlm.nih.gov/pubmed/22211691

Curr Pharm Des. 2012;18(1):91-9.

Curcumin: a potential neuroprotective agent in Parkinson's disease

Abstract

Parkinson's disease (PD) is an age-associated neurodegenerative disease clinically characterized as a movement disorder. The motor symptoms in PD arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. Most of the current pharmacotherapeutic approaches in PD are aimed at replenishing the striatal dopamine. Although these drugs provide symptomatic relief during early PD, many patients develop motor complications with long-term treatment. Further, PD medications do not effectively tackle tremor, postural instability and cognitive deficits. Most importantly, most of these drugs do not exhibit neuroprotective effects in patients. Consequently, novel therapies involving natural antioxidants and plant products/molecules with neuroprotective properties are being exploited for adjunctive therapy. Curcumin is a polyphenol and an active component of turmeric (Curcuma longa), a dietary spice used in Indian cuisine and medicine. Curcumin exhibits antioxidant, anti-inflammatory and anti-cancer properties, crosses the blood-brain barrier and is neuroprotective in neurological disorders. Several studies in different experimental models of PD strongly support the clinical application of curcumin in PD. The current review explores the therapeutic potential of curcumin in PD.

Interesting blog with a compilation of research. http://parkinsonsand5htp.blogspot.com/2012/04/turmericcurcumin-great-promise-for.html

No human embryo had to die for this experiment!

Remember how the left vilified Bush for not approving the expansion of the embryonic stem cell lines on the federal dollar? (It never was illegal and there was no ban--private money was OK to do so and it has never produced a single successful treatment.) Meanwhile adult stem cell research surged ahead. When Obama stepped up in 2009 he kept one of his first promises--expanding embryonic stem cell research. But it was too late even for that purely political move. It isn't needed. A hollow promise from a morally hollow man.

"Transplantation of human endometrial–derived stem cells (HEDSC) [HEDSC ARE ADULT STEM CELLS FROM THE ENDOMETRIUM] into mice with a Parkinson disease-like disorder boosted the animals’ dopamine production, according to a study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The findings provide preliminary evidence that such transplantation may have therapeutic benefits in Parkinson disease. . .

"The authors noted that HEDSC can be easily obtained through a routine office procedure, and that women with Parkinson disease might be transplanted with their own cells." JAMA June 23/30, 2010, v. 303 n.24, p. 2464

Now admit it, NOW. Isn't that better than womb farming women for embryos?

Supporting a friend

Do you need any of these handsome artistic products? Creation Source Image. Gary has Parkinson's Disease. See Gary's story.

Michael J. Fox Foundation awards 9 grants

"$2.4 million has been awarded to nine research teams to validate nine promising therapeutic targets in Parkinson's disease. To attract an industry sponsor with the resources and expertise to chaperone any new therapeutic requires a critical mass of evidence. This award could help any one of the nine teams bring a target to the point where optimization, preclinical work and ultimately clinical testing, will be viable. Projects funded in this cohort of Target Validation awardees fall into three categories: targets for therapies to alleviate symptoms of PD; approaches focused on dyskinesias, the excessive, uncontrollable movements brought on by long-term dopamine replacement therapy; and targets with potential to slow or stop progression of Parkinson's." From The Alchemist, July 23

Here's an item from 2007 on the circumstances of his illness, his first book, and his second, which was supposed to be out by now, but I haven't seen it. It also includes an inaccurate reference to the dust up over his 2006 campaign ads--I was listening to Rush Limbaugh that day, and know he didn't say what he was accused of by liberals--rarely are they accurate in their interpretation. The media watch dogs, always looking for an opportunity to bash talk radio, really rose to the occasion making a molehill into a volcano. The real moral issue, killing embryos for stem cell research, the left never wants to address. But Fox's viewpoint that he is "lucky" is inspiring to read. I really enjoyed his first book. Monday night at Lakeside we'll be seeing "Back to the Future," one of my all-time favorites.