Humanized mice, Covid and bioethics

When I begin to read a medical article, and a phrase introduces a topic with, "Although Florida Governor Ron DeSantis and Texas Governor Greg Abbott have promoted monoclonal antibodies while opposing vaccine and mask mandates, they're not a substitute for Covid-19 vaccines." 

You have to read it carefully, though. They are not against vaccines or masks, only the mandates. Opposing mandates is a political stance. It's about opposing growing totalitarianism, the huge failures of Biden and the lies of Fauci. This journal obviously is political too--JAMA (Journal of the American Medical Association)

But here's my question for medical/scientific folks, because I'm way over my pay grade here: the monoclonal antibodies for Covid preexposure prophylaxis use 'humanized mice" in their development. Is that for testing or is some of that matter passed into our system? Using animals as chimeras is not new, but the bioethics of this seem to only be discussed in some committee locked in a closet in a research institution. Maybe in Wuhan?

'Humanized mice': Chimeras fuel quest to treat chronic diseases, cancer and even COVID-19 - Genetic Literacy Project

Part mouse, Part human - Science in the News (harvard.edu)