Children, wanted and unwanted

It's a great imponderable. My faith and church informs me that God loves all his children, from conception to old age death, both those who know him and those who don't, the ones with blessings and the ones without. For now, I'll just have to trust that, because I don't always see it working in real time and place.

I'm thinking about little three year old Zack (not his real name) who is actually wanted by two different foster families who have been sharing custody of him for a year and a half. The original foster family who raised Zack from birth have negotiated every legal delay and trick to keep him, and although they signed off from the beginning on plans to adopt him (were told this was not an option), it is obviously their goal. The other foster family, which immediately stepped up to the plate when the state discovered it even existed (months after his birth), is Zack's uncle and his wife, who also raised his half sibling. Zack's birth parents are totally incapable of caring for child (although they have visitation rights) both by behavior and intelligence--the mother being mentally challenged and the father being the boyfriend of her mother (grandmother of the child--remember the movie "Precious?") who took advantage of the woman's low intelligence and had sex with her. So here's a little guy loved too much by people who are asking the court to split him down the middle. On the sidelines, I'm left to ponder what motivates people to even agree to raise a child of such doubtful intellectual heritage and future possibilities and problems--but I'm glad there are people willing to take such risks. That's a risk God takes with us, and one we don't see that often at our level. Both a stranger and a relative took him in and want him, and are now fighting over him with lawyers, judges, guardian ad litem, social workers and child psychologists in pitched battle over a little guy who is happy and well adjusted with both families.

The other special group of children God loves are those with Down and Fragile X syndromes. If you keep up with news from the pro-life community, or have followed the vilification of Sarah Palin and her Down Syndrome child born shortly before she was selected by McCain as a running mate in 2008, you know that over 90% of the children are now aborted after pregnancy testing reveals their condition. This has all sorts of ramifications for other families with mentally challenged children, because these families were strong backers of special health benefits, legislation and schooling for their children. They are now out of the advocacy business. But recently a mouse model in which the critical gene is knocked out has been developed that allows researchers to probe the synapses of brain neurons. Even later in life, mice with Down syndrome or fragile X syndrome (FXS) that are given targeted treatment can experience improvements in cognitive function. Findings from such animal studies have paved the way to human trials. And things are moving rather quickly. There is hope on the horizon that there will be therapeutics developed to help those with the most severe symptoms of stereotypic behavior, hyperactivity and inappropriate speech (Sci Transl Med. 2001:3[64] 64ral).

Other drugs are also being tested that show improved cognition in mouse models. One little mouse model, Ts65Dn, has been particularly useful in testing for memory deficits. This is wonderful news--but comes much too late for so many children killed before they saw the light of day. I wish all children, challenged or blessed with good health, could be as loved as little Trig Palin.

If the therapies under study for FXS and Down syndrome prove effective, the approach may have implications for other developmental disorders that involve invtellectual impairment or autism-like symptoms, or even more common disorders like Alzheimer Disease. The brain is more plastic than ever before imagined. (Summary of material from JAMA Jan. 26, 2011)