301 Church of the Holy Amyloid

Sharon Begley seems to be fighting a one woman science journalist battle--two articles in the Wall Street Journal about the amyloid hypothesis and Alzheimer’s. She points out in her first article on April 9 that after 20 years of following the theory that the disease is caused by the accumulation of sticky plaques made of beta-amyloid, maybe it’s time to look at alternative theories. Brain autopsies of many elderly that have amyloid plaques do not have any symptoms of Alzheimer’s--some normal brains have more amyloid than Alzheimer brains. She writes quoting a researcher: “Powerful people in this field think that amyloid causes Alzheimer’s and won’t consider research that questions the amyloid hypothesis.” Results of alternative research was published in the journal Neuron.

Her second article on April 16 concerns the difficulty of funding research and then publishing anything that goes against “Church of the Holy Amyloid.” In the Journal of Neural Transmission Glenda Bishop published her research that showed rat brains injected with beta-amyloid suffered no more cell death than brains injected with salt water. Researchers looking at other possibilities have seen their grants evaporate. The challenges rest on solid science, claims Begley, but because amyloid research has dominated Alzheimer’s research for so long, almost all the experimental drugs and vaccines in the pipeline are predicated on that.