- Around 3,800 people have been killed in suicide attacks and bombings, blamed on homegrown Taliban and other armed groups across Pakistan, since government troops stormed the Red Mosque in Islamabad three years ago.
The Karachi bombing came less than a week after a suicide bombing on a mosque packed with worshippers killed 68 people in northwest Pakistan.
Karachi has already suffered its most serious bout of political violence in years, with 85 people killed after a politician was shot dead in August.
The city is Pakistan's economic capital, home to its stock exchange and a strategic port where Nato docks its supplies ready to be transported overland to support the war in Afghanistan.
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