Friday, October 10, 2008

Cells from human testes superior to embryonic stem cells

was the headline in the paper October 8. Well, good. They can start using men as cell farms and poking and proding them instead of pregnant women. If GWB never did one more good thing in his life time other than these three, 1) appoint two outstanding judges to the Supreme Court, 2) stay focused in Iraq and not turn tail and run out on the people he liberated, and 3) hold the line on growing embryos so the guys in lab coats could experiment, then he should go down in history as our finest President. Ever.
    Abstract: "Human primordial germ cells and mouse neonatal and adult germline stem cells are pluripotent and show similar properties to embryonic stem cells. Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice. The human adult germline stem cells differentiated into various types of somatic cells of all three germ layers when grown under conditions used to induce the differentiation of human embryonic stem cells. We conclude that the generation of human adult germline stem cells from testicular biopsies may provide simple and non-controversial access to individual cell-based therapy without the ethical and immunological problems associated with human embryonic stem cells." Nature, online Oct. 8, 2008
    "On Aug. 9, 2001, Bush announced his decision on federal funding for embryonic stem cell research in an address to the nation. He said only research on stem cell lines already in existence by the time of his speech would be eligible for federal funding.

    He said research on these stem cell lines was permissible because an embryo had already been destroyed. But federal funding would not be allowed for research on any stem cell line created after Aug. 9, 2001, as to discourage future embryo destruction. However, privately funded human embryonic stem cell research has remained permissible on either the “existing” human lines or on lines derived after August 9, 2001.

    At the time of the address, the National Institutes of Health determined that there were 64 stem cell lines in existence. However, researchers have expressed doubts about how many lines are actually available for use, whether the cells provided enough genetic diversity and whether the lines are contaminated with animal cells. On Sept. 5, 2001, Thompson acknowledged that only 24 or 25 of the cell lines were established embryonic stem cell lines.

    On Nov. 7, 2001, the NIH Human Embryonic Stem Cell Registry was launched. It lists all the cell lines that are eligible for federally funded research, as well as contact information for researchers who wish to use them."
    Stem Cell Research 101
And I should give Bill Clinton and Congress of the late 1990s some credit too, who held the line all through the 90s with just a little slip up in 2000, which opened up those original lines for research. The U.S. never fell behind on stem cell research, in fact it led the world. It was only the federal money that was restricted--and my goodness, look what you can accomplish! You wouldn't know that if you only let NYT or WaPo form your opinions about the value of human life.

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